How can I accelerate Zope ?
Until recently, we have had a lot of trouble with Zope performance: memory explosion (leaks?), poor Web performance, unexpected restarts, etc. In order to circumvent those issues, we first created a static directory in Apache to bypass Zope completely for big files. However, that was very unconvenient for a community site. We probably could finally solve most issues with the setup described bellow.
URL: http://www.nexedi.org/Members/jp/faq/accelerate-zope.stx

Use ZEO with Zope
ZEO will help you scale your site and give redundancy/high availability to your site too. Every Zope installation will be a Client Storage (CS) that talks to the Zope Storage Server (ZSS). Every CS will have its own object cache and will be able to work independently of other CS.
URL: http://www.zope.org/Members/kedai/UseZeoZope  

Python 2.1.x, Zope 2.5.x, Apache 1.3.x/2.0.x, Virtual Hosts and caching installation and startup on RedHat Linux 7.3 and beyond
This new version of the RedHat startup HOW-TO will explain how to setup Zope (2.5.1) on a machine with a RedHat Linux distribution (or similar distros) 7.3 or superior with or without Apache. The new thing is that we have to fix a little problem: RedHat ships Python 2.0 and 2.2, but not 2.1 (and will never ship that version since they have switched to only 2.2 in the RawHide). So we will have to download and install Python 2.1 too (until Zope will switch to 2.2).
URL: http://www.zope.org/Members/markoer2/
resources/howtos/redhat_7.3_startup

File System Cache Manager
An alternative approach to caching web sites. There are three main ways of caching a web site at the moment, using a HTTP Accelerated Cache Manager, a RAM Cache Manager and using an external proxy to do the caching such as Squid or Apache. This is just another approach, its not exactly a brilliant approach and like all the others its not perfect but it is very fast and easy to set up.
URL: http://www.zope.org/Members/andym/FSCacheManager

Edge Side Includes (ESI)
Dynamische Webseiten lassen sich durch die W3C-Submission "Edge-Side-Includes"-Technik (ESI) zwischenspeichern. ESI-fähige Caches nehmen Application-Server einen Teil der Last bei dynamischen Webseiten ab. Ab Zope 2.7 soll laut Angaben der Zope Corporation eine ESI-basierte Kommuniktaion mit dem Caching-Server Squid möglich werden. Folgende Publikationen liefern einen Einstieg:

Zope Corporation Announces Open Source ESI Implementation, October 30, 2002
http://www.zope.com/News/PressReleases/OpenSourceESI

Edge Side Includes (ESI) Overview
http://www.edge-delivery.org/overview.html

ESI Language Specification 1.0, W3C Note 04 August 2001
http://www.w3.org/TR/esi-lang

Doug Allen: Edge Side Includes; Network Magazine, 08/04/02
http://www.networkmagazine.com/article/NMG20020804S0004

Caching dynamischer Webseiten mit ESI; networkcomputing.de-Workshop, Ausgabe
9-10/2002 17. Mai 2002
http://www.networkcomputing.de/workshop/workshop%202002/ws_091002.html